Equipment for OECD Test guideline 437 to determine eye irritation in vitro (BCOP)

Chemical hazard identification includes the assessment of eye irritation potential. As of September 2009, the OECD permits in vitro tests with isolated bovine cornea to be used as a replacement of in vivo tests on rabbit eyes.

During the in-house validation of the BCOP assay, BASF discovered that it was difficult to commercially obtain reliable state-of-the-art equipment. Therefore BASF redefined the state-of-the-art by designing and optimizing the instrumentation for BCOP evaluation. The BCOP Opacitometer Kit offers a solution, including standardized equipment calibrated by certified glass filters, to generate reproducible and comparable results across laboratories. Since the adoption of OECD TG 437, many labs have recognized the value of our opacitometer kit and have requested it to ensure the quality of their data.

In 2014 BASF SE transferred the Opacitometer business to DURATEC Analysentechnik GmbH.

Cornea Holder
Cornea Holder(demounted)
Cornea Holder
Cornea Holder

 Take a look at our video tutorial, to see how the instruments works.